Perks are mostly weapon-independent abilities that make your COD4 alter ego more durable, fitter for extended sprints, more lethal with guns, more proficient with explosives, and so on. It'll take a bit of experimenting and experience before you find out which perks and which weapons work for your playing style. If you keep getting stabbed in the back by some sneaky player, or lose a lot of close encounters, consider picking the Martyrdom perk. It'll make you drop a live grenade every time you die, and you'll probably take one or more enemies down with you. Of course, a cheeky sneak will just grab your grenade and toss it at your mates anyway.

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